Benzhydrylpiperazine → HCID 67235139, compound

Participants

Reaction Steps

5-Phenyl-3-(3,4,5-trimethoxybenzoyl)-oxazolidine-4-carboxylic acid (12) (120 mg; 0.310 mmol) is dissolved in methylene chloride (3 mL) at ambient temperature. 1-(Diphenylmethyl)piperazine (94 mg; 0.372 mmol), N,N-diisopropylethylamine (128 mg; 0.99 mmol) and PyBOP (193 mg; 0.372 mmol) are added sequentially. The reaction is stirred for 1 hour at room temperature, then concentrated under reduced pressure. The residue is purified via silica gel chromatography (30%→60% ethyl acetate in hexanes) affording the desired product as a white solid. CIMS: MH+ 622

Provenance & Evidence