Benzhydrylpiperazine → HCID 131724628, compound

Participants

Reaction Steps

N-(tert-Butoxycarbonyl)-3-phenyl-[(2S)-2-pyrrolidinecarboxylic acid] (14) (1.50 g; 5.1 mmol) prepared according to Chung, J. Y. et al., J. Org Chem. 55:270-5 (1990) is dissolved in methylene chloride (55 mL) at ambient temperature. 1-(Diphenylmethyl)piperazine (1.62 g; 6.4 mmol), N,N-diisopropylethylamine (1.50 g; 2.25 mmol) and PyBOP (3.35 g; 6.4 mmol) are added sequentially. The reaction is stirred for 18 hours at room temperature, then concentrated under reduced pressure. The residue is purified via silica gel chromatography (33%→50% ethyl acetate in hexanes) affording the desired product as a white solid. CIMS: MH+ 526

Provenance & Evidence