Trifluoroacetic acid → HCID 86585769, compound

Participants

Reaction Steps

N-(tert-Butoxycarbonyl)-3-phenyl-[(2S)-2-pyrrolidinecarboxylic acid] (4-benzhydrylpiperazine-1-yl) amide (15) (2.70 g; 5.14 mmol) is dissolved in methylene chloride (30 mL) at ambient temperature. Trifluoroacetic acid (20 mL) is added in a slow stream, and the solution is stirred for 2 hours at ambient temperature. The reaction mixture is cooled in an ice-bath and the pH adjusted to 9 with saturated potassium carbonate solution. The mixture is poured onto water (30 mL) and extracted with methylene chloride (1×60 mL, 2×20 mL). The combined organic extracts are washed with water, dried over MgSO4, filtered, and concentrated in vacuo affording the desired product. CIMS: MH+ 426

Provenance & Evidence