反应详情

To a solution of 5.00 g (23.5 mmole) 2-hydroxy-5-methyl-benzophenone and 6.67 g (47.1 mmole) methyliodide in 50 ml abs. acetone 4.50 g (32.6 mmole) potassium carbonate are added. The reaction mixture is then heated for 5 hours with recycling. Following cooling, 50 ml water and 50 ml petroleum ether (30/60) are added to the suspension. The organic phase is separated off, the aqueous phase is extracted twice with 75 ml petroleum ether (30/60) and the purified organic phase is washed twice with 50 ml 10% NaOH solution. The organic phase is then dried through magnesium sulphate and the solvent is removed. 3.80 g (16.8 mmole, 71%) 2-methoxy-5-methyl-benzophenone are obtained.

1. temperatureThe reaction mixture is then heated for 5 hours
2. temperatureFollowing cooling
3. customThe organic phase is separated off
4. extractionthe aqueous phase is extracted twice with 75 ml petroleum ether (30/60)
5. washthe purified organic phase is washed twice with 50 ml 10% NaOH solution
6. dry with materialThe organic phase is then dried through magnesium sulphate
7. customthe solvent is removed