Triethylamine → HCID 22648420, compound

Participants

Reaction Steps

To a solution of 1.31 g (4.5 mmole)2-[4-methyl-2-(1-phenyl-vinyl)-phenoxymethyl]-pyrrolidine and 1.13 g (11.2 mmole) triethylamine in 12 ml abs. toluene at 0° within 30 minutes 1.00 g (4.6 mmole) P-chlorodiphenylphosphine in 3 ml abs. toluene are added dropwise. The reaction solution is left under agitation at RT for 20 h. Then the resultant triethylammonium chloride is filtered off, the residue is recleaned with 20 ml toluene and the filtrate is reduced on the rotary evaporator. Cleaning of the raw product obtained takes place by column chromatography on silica gel with MTBE/cyclohexane/diisopropylamine (ratio of volumes=5/1+10 Vol−%) as the eluant. 1.31 g (2.7 mmole, 61%)diphenylphosphanyl-[4-methyl-2-(1-phenyl-vinyl)-phenoxymethyl]-pyrrolidine are obtained.

Provenance & Evidence