Morpholine → HCID 12043587, compound

Participants

Reaction Steps

0.421 g (2.0 mmole) 4-methyl-2-(1-phenyl-vinyl)-phenol, 0.10 ml (1.15 mmole) morpholine, 6.0 mg (12 μmole) [RhCl(cod)]2 and 10 ml abs. dioxane are agitated in a pressure vessel for 3 days at 120° C. and under a pressure of 90 bar synthesis gas (CO:H2=7.2). Following cooling and relieving of the pressure vessel, the reaction solution undergoes absorptive filtering (eluant: diethylether, then ethanol) through aluminium oxide (activity II-III, basic). Following removal of the solvent, the cleaning of the raw product takes place by column chromatography on silica gel with cyclohexane/MTBE (ratio of volumes=1/1) as the eluant. 255 mg (0.82 mmole, 82%) 4-methyl-2-(3-morpholin-4-yl-1-phenyl-propyl)-phenol are obtained.

Provenance & Evidence