HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 69100997, compound → HCID 69100859, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 69100997 | HCID 69100997 | — |
| Catalyst | HCID 178502593 | HCID 178502593 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | HCID 178418361 | HCID 178418361 | — |
| Product | HCID 69100859 | HCID 69100859 | 102.3% |
Reaction Steps
To a solution of 2.49 g of (2R)-1-benzyloxycarbonyl-N-({(3R)-1-(tert-butoxycarbonyl)-3-piperidyl}methyl)pyrrolidine-2-carboxamide in 20 ml of methanol, 15 mg of 20% palladium hydroxide-carbon catalyst was added, followed by 5 hours' stirring in hydrogen atmosphere. After filtering the catalyst off, the solvent was distilled off under reduced pressure to provide 1.78 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06809108B1 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-4846beb3f0e04a5599a839e4f2a72d65 |
| Source note | uspto-grants-2004_10 |