1-Boc-4-(aminomethyl)piperidine → (2R)-1-[(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidine-2-yl]carbonyl-N-(4-piperidinylmethyl)pyrrolidine-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	1-Boc-4-(aminomethyl)piperidine	HCID 736817	—
Reactant	(2R)-1-{(2S,4R)-4-(tert-butoxy)-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonylpyrrolidine-2-carboxylic acid	HCID 69100730	—
Product	(2R)-1-[(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidine-2-yl]carbonyl-N-(4-piperidinylmethyl)pyrrolidine-2-carboxamide	HCID 16086003	—

Reaction Steps

The title compound was prepared by successively conducting procedures which were similar to Step 5 of Example 1 and Example 46, using (2R)-1-{(2S,4R)-4-(tert-butoxy)-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonylpyrrolidine-2-carboxylic acid and 4-aminomethyl-1-(tert-butoxycarbonyl)piperidine. The compound was obtained as a colorless oily substance.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06809108B1
Source dataset	uspto-grants-2004_10
ORD ID	ord-b623cef97e924f379a7d893ab851e0da
Source note	uspto-grants-2004_10