HRID394037

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13207

Cyclohexyl methyl ketone

C8H14O

结构：O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1

HCID16086004

未命名化合物

PRODUCTS

生成物

结构：CC(C1CCCCC1)N1CCC[C@@H](CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccccc2)(c2ccccc2)c2ccccc2)C1

HCID69100804

未命名化合物

PROCEDURE

实验过程

The title compound was prepared by a method similar to Step 3 of Example 17, using (2R)-1-{(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonyl-N-((3R)-3-piperidylmethyl)pyrrolidine-2-carboxamide and cyclohexyl methyl ketone. The compound was obtained as a white solid.

WORKUP

后处理

customThe compound was obtained as a white solid

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c6b0e5bb7752470aadca9ae1dd3cf7aa
来源数据集: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06809108B1
来源说明: uspto-grants-2004_10

反应 SMILES

[OH:1][C@H:2]1[CH2:6][N:5]([C:7](=[O:28])[CH2:8][C:9]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C@H:4]([C:29]([N:31]2[CH2:35][CH2:34][CH2:33][C@@H:32]2[C:36]([NH:38][CH2:39][C@@H:40]2[CH2:45][CH2:44][CH2:43][NH:42][CH2:41]2)=[O:37])=[O:30])[CH2:3]1.[CH3:46][C:47]([CH:49]1[CH2:54][CH2:53][CH2:52][CH2:51][CH2:50]1)=O>>[CH:49]1([CH:47]([N:42]2[CH2:43][CH2:44][CH2:45][C@@H:40]([CH2:39][NH:38][C:36]([C@H:32]3[CH2:33][CH2:34][CH2:35][N:31]3[C:29]([C@@H:4]3[CH2:3][C@@H:2]([OH:1])[CH2:6][N:5]3[C:7](=[O:28])[CH2:8][C:9]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[O:30])=[O:37])[CH2:41]2)[CH3:46])[CH2:54][CH2:53][CH2:52][CH2:51][CH2:50]1