1-Iodopropane → HCID 69101078, compound

Participants

Reaction Conditions

Reaction Steps

To 4.9 mg of (2R)-1-{(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl)carbonyl-N-{((3S)-1-propyl-3-piperidyl)methyl}pyrrolidine-2-carboxamide, 1 ml of propyl iodide was added at room temperature, followed by 15 hours' stirring at 100° C. under heating. The reaction liquid was diluted with chloroform, the solvent was distilled off under reduced pressure, and the resulting residue was purified with preparative thin-layer chromatography (aluminium oxide 60F254, Art 5713 (Merck), chloroforom/methanol=18/1) to provide 4.1 mg of the title compound as a pale yellow solid.

Provenance & Evidence