1-(2-Hydroxyethyl)piperazine → 1-(2,6-Dichlorophenyl)-5-(2,4-difluorophenyl)-3,4-dihydro-7-[2-(1-piperazinyl)ethoxy]-2(1H)-quinolinone

Participants

Reaction Steps

1-(2,6-Dichlorophenyl)-5-(2,4-difluorophenyl)-3,4-dihydro-7-[2-(1-piperazinyl)ethoxy]-2(1H)-quinolinone was prepared from 1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-3,4-dihydro-7-hydroxy-2(1H)-quinolinone (INTERMEDIATE 3) and 1-piperazine ethanol by a procedure analogous to that described in EXAMPLE 2. Mass spectrum (ESI) 532.3 (M+1). 1H NMR (500 MHz, CDCl3): δ 7.51 (d, J=8.5 Hz, 2H); 7.36 (t, J=8 Hz, 1H); 7.29 (q, J=6 Hz, 1H); 6.96 (m, 2H); 6.52 (s, 1H); 5.90 (s, 1H); 3.96 (t, J=5.5 Hz, 2H); 2.88 (m, 4H); 2.70 (m, 4H); 2.47 (br, 4H); 2.10 (br, 2H).

Provenance & Evidence