反应详情

1-(2,6-Dichlorophenyl)-5-(2,4-difluorophenyl)-7-hydroxy-2(1H)-quinolinone was prepared from 1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-methoxy-2(1H)-quinolinone (INTERMEDIATE 4) by a procedure analogous to that described in INTERMEDIATE 3. Mass spectrum (ESI) 418.0 (M+1). 1H NMR (500 MHz, CDCl3): δ 7.57 (d, J=8 Hz, 1H); 7.47 (d, J=7.5 Hz, 2H); 7.33 (m, 2H); 7.02 (m, 2H); 6.96 (s, 1H); 6.52 (d, J=9.5, 1H); 6.01 (s, 1H).