1-(2,6-Dichlorophenyl)-5-(2,4-difluorophenyl)-3,4-dihydro-7-hydroxy-2(1H)-quinolinone → 5-(2-Chlorophenyl)-1-(2,6-dichlorophenyl)-3,4-dihydro-7-hydroxy-2(1H)-quinolinone

Participants

Reaction Steps

5-(2-Chlorophenyl)-1-(2,6-dichlorophenyl)-3,4-dihydro-7-hydroxy-2(1H)-quinolinone was prepared from 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone (INTERMEDIATE 6) by a procedure analogous to that described in INTERMEDIATE 3 Mass spectrum (ESI) 418.1 (M+1). 1H NMR (500 MHz, CDCl3): δ 7.43-7.52 (m, 2H); 7.22-7.40 (m, 4H); 6.38 (d, J=2.5 Hz, 1H); 5.82 (d, J=2.5 Hz, 1H); 2.58-2.85 (m, 4H).

Provenance & Evidence