5-(2-Chloro-5-fluorophenyl)-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone → 5-(2-Chloro-5-fluorophenyl)-1-(2,6-dichlorophenyl)-3,4-dihydro-7-hydroxy-2(1H)-quinolinone

Participants

Reaction Steps

5-(2-Chloro-5-fluorophenyl)-1-(2,6-dichlorophenyl)-3,4-dihydro-7-hydroxy-2(1H)-quinolinone was prepared from 5-(2-chloro-5-fluorophenyl)-1-(2,6-dichlorophenyl)-3,4dihydro-7-methoxy-2(1H)-quinolinone (INTERMEDIATE 10) by a procedure analogous to that described in INTERMEDIATE 3. Mass spectrum (ESI) 438.1 (M+1). 1H NMR (500 MHz, CDCl3): δ 7.49 (d, J=7.5 Hz, 2H); 7.36 (t, J=8 Hz, 1H); 7.27 (m, 2H); 7.07 (m, 1H); 6.38 (s, 1H); 5.83 (s, 1H); 2.73 (m, 4H).

Provenance & Evidence