(4-Fluoro-2-methylphenyl)boronic acid → 3,4-dihydro-5-(4-fluoro-2-methylphenyl)-7-methoxy-2(1H)-quinolinone

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Reaction Steps

1-2,6-Dichlorophenyl)-3,4-dihydro-5-(4-fluoro-2-methylphenyl)-7-methoxy-2(1H)-quinolinone was prepared from 5-bromo-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone (INTERMEDIATE 1) and 4-fluoro-2-methylphenylboronic acid by a procedure analogous to that described in INTERMEDIATE 2. Mass spectrum (ESI) 430.1 (M+1). 1H NMR (500 MHz, CDCl3): δ 7.50 (m, 2H); 7.36 (m, 1H); 7.17 (m, 1H); 6.98 (m, 2H); 6.45 (s, 1H); 5.89 (s, 1H); 3.69 (s, 3H); 2.72 (m, 4H); 2.15 (s, 3H).

Provenance & Evidence