反应详情

5-Bromo-3,4-dihydro-7-methoxy-1-(3-methoxycarbonyl-6-methylphenyl)-2(1H)-quinolinone was prepared from N-(3-methoxycarbonyl-6-methylphenyl)-3-(2,6-dibromo-4-methoxyphenyl)-propionamide by a procedure analogous to that described in INTERMEDIATE 1, Step E. Mass spectrum (ESI) 374.0 (M-OMe). 1H NMR (500 MHz, CDCl3): δ 8.02 (dd, J=2.0, 8.0 Hz, 1H); 7.80 (d, J=8.5 Hz, 1H); 6.80 (d, J=2.5 Hz, 1H); 5.73 (d, J=2.5 Hz, 1H); 3.89 (s, 3H); 3.63 (s, 3H); 3.16 (m, 2H); 2.80 (m, 2H); 2.13 (s, 3H).