反应详情

5-(2,4-Difluorophenyl)-3,4-dihydro-7-hydroxy-1-(3-methoxycarbonyl-6-methylphenyl)-2(1H)-quinolinone was prepared from 5-bromo-3,4-dihydro-7-methoxy-1-(3-methoxycarbonyl-6-methylphenyl)-2(1H)-quinolinone (INTERMEDIATE 15) by a procedure analogous to that described in INTERMEDIATE 3. Mass spectrum (ESI) 424.1 (M+1). 1H NMR (500 MHz, DMSO-d6): δ 9.44 (s, 1H); 7.96 (d, J=8.0 Hz, 1H); 7.75 (s, 1H); 7.59 (d, J=8.0 Hz, 1H); 7.41 (m, 2H); 7.18 (t, J=6.0 Hz, 2H); 6.33 (s, 1H); 5.63 (s, 1H); 3.84 (s, 3H); 2.61 (m, 4H); 2.09 (s, 3H).