5-(2-Chlorophenyl)-3,4-dihydro-7-methoxy-1-(3-methoxycarbonyl-6-methylphenyl)-2(1H)-quinolinone → 5-(2-Chlorophenyl)-3,4-dihydro-7-hydroxy-1-(3-methoxycarbonyl-6-methylphenyl)-2(1H)-quinolinone

Participants

Role	Name	HCID	Charge
Reactant	5-(2-Chlorophenyl)-3,4-dihydro-7-methoxy-1-(3-methoxycarbonyl-6-methylphenyl)-2(1H)-quinolinone	HCID 22648057	—
Reactant	1-(2,6-Dichlorophenyl)-5-(2,4-difluorophenyl)-3,4-dihydro-7-hydroxy-2(1H)-quinolinone	HCID 22648093	—
Product	5-(2-Chlorophenyl)-3,4-dihydro-7-hydroxy-1-(3-methoxycarbonyl-6-methylphenyl)-2(1H)-quinolinone	HCID 22648035	—

Reaction Steps

5-(2-Chlorophenyl)-3,4-dihydro-7-hydroxy-1-(3-methoxycarbonyl-6-methylphenyl)-2(1H)-quinolinone was prepared from 5-(2-chlorophenyl)-3,4-dihydro-7-methoxy-1-(3-methoxycarbonyl-6-methylphenyl)-2(1H)-quinolinone (INTERMEDIATE 17) by a procedure analogous to that described in INTERMEDIATE 3. Mass spectrum (ESI) 422.2 (M+1). 1H NMR (500 MHz, CDCl3): δ 7.93 (d, J=7.5 Hz, 1H); 7.85 (d, J=17.5 Hz, 1H); 7.49 (m, 3H); 7.7.26 (m, 1H); 6.34 (s, 1H); 5.78 (s, 1H); 3.85 (s, 3H); 2.62 (m, 4H); 2.14 (d, J=10.5 Hz, 3H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06809199B2
Source dataset	uspto-grants-2004_10
ORD ID	ord-27c55d2088664cd7abe31b8928b13d5b
Source note	uspto-grants-2004_10