HCID 22647914, compound → HCID 22648046, compound

Participants

Reaction Steps

The title compound was prepared from 1-(2,6-dichlorophenyl)-3-methyl-5-(2-chloro-4-fluorophenyl)-7-trifluoromethylsulfonato-3,4-dihydro-2(1H)-quinazolinone as described in EXAMPLE 41. 1-(2,6-dichlorophenyl)-3-methyl-5-(2-chloro-4-fluorophenyl)-7-trifluoromethylsulfonato-3,4-dihydro-2(1H)-quinazolinone was prepared from 1-(2,6-dichlorophenyl)-3-methyl-5-(2-chloro-4-fluorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinazolinone (INTERMEDIATE 58) as described in INTERMEDIATE 48 and INTERMEDIATE 60. 1H NMR(CDCl3, 500 MHz): diastereomeric atropisomers δ 1.32 (m, 3H), 2.37 (brs, 2H), 2.51 (brm, 1H), 3.10 (t, 2H, J=5.7 Hz), 3.53 (brs, 2H), 4.36 (m, 0.5H), 4.47 (m, 0.5H), 5.51 (d, 0.5H, 2.9 Hz), 5.58 (d, 0.5H, J=2.7 Hz), 5.90 (brs, 1H), 6.13 (s, 0.5H), 6.15 (s, 0.5H), 6.83 (s, 0.5H), 6.90 (s, 0.5H), 7.09-7.13 (m, 1H), 7.28-7.42 (m, 3H), 7.51-7.58 (m, 2H). MS(ES) 516 (M+H); LC 1: 2.22 min.

Provenance & Evidence