5-(2-Chlorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2,3,4-tetrahydroquinazoline-7-carbaldehyde → 1-Allyl 2-tert-butyl 4-{[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2,3,4-tetrahydroquinazolin-7-yl]methyl}piperazine-1,2-dicarboxylate

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Reaction Steps

The 1-allyl 2-tert-butyl 4-{[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2,3,4-tetrahydroquinazolin-7-yl]methyl}piperazine-1,2-dicarboxylate was prepared from 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2,3,4-tetrahydroquinazoline-7-carbaldehyde (INTERMEDIATE AAA1) and 1-allyloxycarbonyl-2-t-butyloxycarbonyl piperazine as described in EXAMPLE AAA1, STEP A. 1H NMR (CDCl3, 500 MHz): 1.34 (s, 9H), 1.92 (m, 1H), 2.26 (m, 1H), 2.70 (m, 1H), 3.12 (m, 1H), 3.30 (m, 3H), 3.50 (m, 1H), 3.83 (m, 1H), 4.34 (abq, 2H, J=14.4 Hz), 4.54 (m, 1H), 4.62 (brs, 2H), 5.03 (s, 1H), 5.16-5.36 (m, 2H), 5.93 (brs, 1H), 6.11 (s, 1H), 6.85 (d, 1H, J=10.1 Hz), 7.32-7.56 (m, 7H). MS (API-ES+): 687 (M+H).

Provenance & Evidence