HCID 22648179, compound → HCID 22648041, compound

Participants

Reaction Conditions

Reaction Steps

5-(2-Chlorophenyl)-1-(2,6-dichlorophenyl)-7-[(4-isopropylpiperazin-1-yl)acetyl]-3-(4-methoxybenzyl)-3,4-dihydroquinazolin-2(1H)-one (36 mg, 0.052 mmol) was dissolved in trifluoroacetic acid (0.8 mL), and this mixture was heated at 70° C. for 30 min. After cooling it down, trifluoroacetic acid was removed by co-evaporation with toluene to give crude product. This was purified by preparative thin layer chromatography using 5% 2M NH3 in MeOH/CH2Cl2 as an eluent to give the title compound. 1H NMR (CDCl3, 500 MHz): δ 7.54-7.29 (m, 8H); 6.94 (s, 1H); 5.44 (s, 1H); 4.47 (d, J=15.6 Hz, 1H); 4.29 (d, J=15.6 Hz, 1H); 3.54 (Abq, J=4.1, 14.9 Hz, 2H); 2.62 (m, 1H); 2.48 (brs, 8H); 1.03 (2 s, 6H). Mass spectrum (ESI): 571.2 (M+1).

Provenance & Evidence