HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-iodo-3-(4-methoxybenzyl)-3,4-dihydroquinazolin-2(1H)-one → 5-(2-Chlorophenyl)-1-(2,6-dichlorophenyl)-7-(5-isopropyl-2,5-diazabicyclo[2.2.1]hept-2-yl)-3-(4-methoxybenzyl)-3,4-dihydroquinazolin-2(1h)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-iodo-3-(4-methoxybenzyl)-3,4-dihydroquinazolin-2(1H)-one | HCID 22647869 | — |
| Reactant | 2-Isopropyl-2,5-diazabicyclo[2.2.1]heptane | HCID 22647900 | — |
| Product | 5-(2-Chlorophenyl)-1-(2,6-dichlorophenyl)-7-(5-isopropyl-2,5-diazabicyclo[2.2.1]hept-2-yl)-3-(4-methoxybenzyl)-3,4-dihydroquinazolin-2(1h)-one | HCID 22648045 | — |
Reaction Steps
The title compound was prepared from 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-iodo-3-(4-methoxybenzyl)-3,4-dihydroquinazolin-2(1H)-one (EXAMPLE CCC34) and using 2-isopropyl-2,5-diazabicyclo[2.2.1]heptane (INTERMEDIATE ABA2) as described in EXAMPLE 80. Mass spectrum (ESI): 661.3 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06809199B2 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-6e615e904f9a4a09a83cec133d1bd750 |
| Source note | uspto-grants-2004_10 |