HRID394129

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(CN2Cc3c(-c4ccccc4Cl)cc(I)cc3N(c3c(Cl)cccc3Cl)C2=O)cc1

HCID22647869

未命名化合物

结构：CC(C)(C)N1CCC(=[CH][Sn]([CH3])([CH3])[CH3])CC1

HCID22647936

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CN2Cc3c(-c4ccccc4Cl)cc(C=C4CCN(C(C)(C)C)CC4)cc3N(c3c(Cl)cccc3Cl)C2=O)cc1

HCID22647949

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-iodo-3-(4-methoxybenzyl)-3,4-dihydroquinazolin-2(1H)-one (EXAMPLE CCC34) and using 1-tert-butyl-4-[(trimethylstannyl)methylene]piperidine (INTERMEDIATE ABA3) as described in EXAMPLE 41, Step A. Mass spectrum (ESI): 674.5 (M+1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5661529feb8243938586ea296fceb380
来源数据集: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06809199B2
来源说明: uspto-grants-2004_10

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:17]=[C:16](I)[CH:15]=[C:14]2[C:9]=1[CH2:10][N:11]([CH2:28][C:29]1[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][CH:30]=1)[C:12](=[O:27])[N:13]2[C:19]1[C:24]([Cl:25])=[CH:23][CH:22]=[CH:21][C:20]=1[Cl:26].[C:37]([N:41]1[CH2:46][CH2:45][C:44](=[CH:47][Sn](C)(C)C)[CH2:43][CH2:42]1)([CH3:40])([CH3:39])[CH3:38]>>[C:37]([N:41]1[CH2:46][CH2:45][C:44](=[CH:47][C:16]2[CH:15]=[C:14]3[C:9]([CH2:10][N:11]([CH2:28][C:29]4[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][CH:30]=4)[C:12](=[O:27])[N:13]3[C:19]3[C:24]([Cl:25])=[CH:23][CH:22]=[CH:21][C:20]=3[Cl:26])=[C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])[CH:17]=2)[CH2:43][CH2:42]1)([CH3:40])([CH3:39])[CH3:38]