(4-Fluoro-3-methylphenyl)boronic acid → 7-(1-tert-Butylpiperidin-4-yl)-1-(2,6-dichlorophenyl)-5-(4-fluorophenyl)quinolin-2(1H)-one

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The title compound was prepared from 5-bromo-7-(1-tert-butyl-1,2,3,6-tetrahydropyridin-4-yl)-1-(2,6-dichlorophenyl)quinolin-2(1H)-one (INTERMEDIATE ABA5) and using 4-fluoro-3-methylphenylboronic acid as described in EXAMPLE ABA11. 1H NMR (CD3OD, 500 MHz): δ 1.252 (s, 9H), 1.734 (bs, 2H), 1.955 (bs, 2H), 2.084 (s, 3H), 2.665 (bs, 4H), 3.307 (m, 1H), 3.394 (bs, 2H), 6.471 (s, 1H), 6.650 (d, J=9.9 Hz, 1H), 7.064 (t, J=5.7 Hz, 1H), 7.123 (s, 1H), 7.146 (dd, J=2.7, 9.9 Hz, 1H), 7.243 (dd, J=5.7, 8.5 Hz, 1H), 7.570 (d, J=9.9 Hz, 1H), 7.616 (t, J=8.5 Hz, 1H), 7.737 (m, 2H). Mass spectrum (ESI): 537.2 (M+1).

Provenance & Evidence