Trifluoroacetic acid → 7-(1-tert-Butylpiperidin-4-yl)-1-(2,6-dichlorophenyl)-5-(4-fluorophenyl)quinolin-2(1H)-one

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Reaction Steps

The title compound was prepared from 5-bromo-7-(1-tert-butyl-1,2,3,6-tetrahydropyridin-4-yl)-1-(2,6-dichlorophenyl)quinolin-2(1H)-one (INTERMEDIATE ABA5) and using 3-trifluoromethylphenylboronic acid as described in EXAMPLE ABA11. 1H NMR (CD3OD, 500 MHz) TFA salt: δ 1.358 (s, 9H), 1.780 (q, J=10.5, 12.8 Hz, 2H), 2.062 (d, J=15.6 Hz, 2H), 2.702 (m, 1H), 3.004 (t, J=13.0 Hz, 2H), 3.612 (d, J=13.0 Hz, 2H), 6.460 (s, 1H), 6.682 (d, J=10.2 Hz, 1H), 7.204 (s, 1H), 7.565 (t, J=8.8 Hz, 1H) 7.672-7.742 (m, 5H), 7.778 (m, 1H), 7.844 (d, J=10.2 Hz, 1H). Mass spectrum (ESI): 573.5 (M+1).

Provenance & Evidence