HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 5-(2-Chlorophenyl)-1-(2,6-dichlorophenyl)-7-[(8-methyl-8-azabicyclo [3.2.1]oct-3-yl)oxy]-1,6-naphthyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 5-bromo-1-(2,6-dichlorophenyl)-7-(hydroxymethyl)-3-(4-methoxybenzyl)-3,4-dihydroquinazolin-2(1H)-one | HCID 22647952 | — |
| Reactant | HCID 22647982 | HCID 22647982 | — |
| Reactant | HCID 178481185 | HCID 178481185 | — |
| Product | 5-(2-Chlorophenyl)-1-(2,6-dichlorophenyl)-7-[(8-methyl-8-azabicyclo [3.2.1]oct-3-yl)oxy]-1,6-naphthyridin-2(1H)-one | HCID 22648126 | — |
Reaction Steps
The title compound was prepared from 100 mg of 7-bromo-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-1,6-naphthyridin-2(1H)-one (COMPOUND HHH2), 147 mg of a ca. 1.4:1 mixture of pseudotropine and tropine (EXAMPLE HHH9, Step A), and 25 mg of NaH by a procedure analogous to that described in COMPOUND HHH6.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06809199B2 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-9fa6abd9efbb43fb9ee083909513095b |
| Source note | uspto-grants-2004_10 |