Azobisisobutyronitrile → HCID 22648068, compound

Participants

Reaction Steps

To a refluxing solution of 7-bromo-1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-3,4-dihydro-1,6-naphthyridin-2(1H)-one (0.747 g) and AIBN (0.03 g) in 30 mL of CCl4 was added recrystallized N-bromosuccinimide (0.302 g). The reaction was stirred at reflux for 1 h, then removed from the heat. DBU (0.23 mL) was added and the mixture was stirred at rt for 15 min. The reaction mixture was washed with 100 mL of saturated sodium bicarbonate and back extracted with 50 mL of dichloromethane. The combined organics were washed with 100 mL of brine, dried with sodium sulfate, and concentrated to give the desired product. Mass spectrum m/z (ESI) 481.3 (M+1).

Provenance & Evidence