Azobisisobutyronitrile → HCID 22647970, compound

Participants

Reaction Steps

To a refluxing solution of 3-[4-chloro-6-(2,4-difluorophenyl)-2-(methylthio)pyrimidin-5-yl]-N-(2,6-dichlorophenyl)propanamide (0.06 g) and AIBN (0.005 g) in 8 mL of CCl4 was added recrystallized N-bromosuccinimide (0.026 g). The reaction was refluxed for 1 h, then removed from the heat. DBU (0.02 mL) was added and the solution was stirred at rt for 15 min. The reaction mixture was washed with 20 mL of saturated sodium bicarbonate and back extracted with 20 mL of CH2Cl2. The organic layer was washed with 20 mL of brine, dried with sodium sulfate, and concentrated to give the desired product. Mass spectrum m/z (ESI) 450.4 (M+1).

Provenance & Evidence