2-(2-Chloro-4-fluorophenyl)-3-methyl-5-nitropyridine → 6-(2-Chloro-4-fluorophenyl)-5-methylpyridin-3-amine

Participants

Reaction Steps

A 250 mL round bottom flask was charged with 2-(2-chloro-4-fluorophenyl)-3-methyl-5-nitropyridine (4 g) and methanol (50 mL). To the flask was added Raney nickel/methanol slurry (approx 4 g). The flask was evacuated and charged with hydrogen several times. The mixture was stirred under a balloon of hydrogen for 2.5 h. The flask was purged with nitrogen. The catalyst was filtered off and the filtrate was concentrated under reduced pressure giving 6-(2-chloro-4-fluorophenyl)-5-methylpyridin-3-amine as an off white solid. Mass spectrum (EST) 237 (M+1).

Provenance & Evidence