HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone | HCID 22648098 | — |
| Product | 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone | HCID 22648119 | — |
Reaction Steps
A solution of 5 in 100 mL of CH2Cl2 was added Et3N (4.28 mL, 30.72 mmol) and 2 (26.88 mmol) in 27 mL of CH2Cl2. After 16 h at rt, it was loaded on silica gel and eluted with EtOAc:hexane=1:3 give 6 (16.62 g). Mass spectrum (ESI) for 6, 703 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06809199B2 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-8d4a30056b8843be8f60e784ea3e6c8a |
| Source note | uspto-grants-2004_10 |