Sodium Hydroxide → [Rac]-2-{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-benzyl}-butyric acid

HRID 394393Notes

Reaction equation

HRID 394393 reaction equation
C([O:3][C:4](=[O:34])[CH:5]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]2[S:21][C:20]([C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=3)=[N:19][C:18]=2[CH3:32])=[CH:11][C:10]=1[CH3:33])[CH2:6][CH3:7])C.[OH-].[Na+]>>[CH3:33][C:10]1[CH:11]=[C:12]([O:15][CH2:16][C:17]2[S:21][C:20]([C:22]3[CH:23]=[CH:24][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:26][CH:27]=3)=[N:19][C:18]=2[CH3:32])[CH:13]=[CH:14][C:9]=1[CH2:8][CH:5]([CH2:6][CH3:7])[C:4]([OH:34])=[O:3]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 68617864[Rac]-2-{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-benzyl}-butyric acid ethyl ester

Product 1

HCID 22647530[Rac]-2-{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-benzyl}-butyric acid

Procedure

In analogy to the procedure described in example 10 d], [rac]-2-{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-benzyl}-butyric acid ethyl ester was treated with 3 N NaOH to obtain [rac]-2-{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-benzyl}-butyric acid as colorless solid.

Workup

  1. customdescribed in example 10 d

Sources & evidence

ORD record
ord-9f939395854649d5afa1232bbca3b2f3
Source dataset
uspto-grants-2004_10
Patent number
US06809110B2

Reaction notes

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