HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ethanol → 5-(2-Methylsulfanylpyrimidin-4-yl)-6-(3-trifluoromethylphenyl)-4,5-dihydro-2H-pyridazin-3-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ethanol | HCID 702 | — |
| Edukt | Ethyl Acetate | HCID 8857 | — |
| Edukt | Hydrazine | HCID 9321 | — |
| Edukt | 3-(2-Methylsulfanylpyrimidin-4-yl)-4-oxo-4-(3-trifluoromethylphenyl)butyric Acid | HCID 18176631 | — |
| Lösungsmittel | Diethyl Ether | HCID 3283 | — |
| Produkt | 5-(2-Methylsulfanylpyrimidin-4-yl)-6-(3-trifluoromethylphenyl)-4,5-dihydro-2H-pyridazin-3-one | HCID 18176626 | — |
Reaktionsschritte
Compound 5 (6.58 g, 17.8 mmol), and ethanol (200 mL) were combined under argon. Hydrazine (835 μL, 26.6 mmol) was added and the resulting solution was heated at reflux for 4 h. The solution was cooled and rotary evaporated. Ethyl acetate was added followed by the addition of ether. The solution was again rotary evaporated to afford a foam (6) which was used as is for the synthesis of 7.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06602872B1 |
| Quelldatensatz | uspto-grants-2003_08 |
| ORD ID | ord-b1dc4c7249894badb5d7628b6661dcce |
| Quellennotiz | uspto-grants-2003_08 |