Sodium borohydride → HCID 57895156, compound

Participants

Reaction Steps

To a solution of (6-amino-pyridin-3-yl)-(2-methoxy-phenyl)-methanone (14 g, 61.4 mol) in CH3OH (150 mL) was added NaBH4 (3.48 g, 92.1 mmol) portion-wise at 0° C. After the addition was completed, the reaction was warmed to room temperature and stirred at room temperature for 1 hr. The solvent was removed in vacuo and water (100 mL) was added to the residue. The mixture was extracted with dichloromethane (100 mL×3). The combined organic layers were washed with saturated solution of NaHCO3 and brine, dried over Na2SO4, filtered and concentrated in vacuo to give a crude product that was used directly in the next step with no further purification.

Provenance & Evidence