Trifluoroacetic acid → HCID 137178926, compound

Participants

Reaction Steps

3 ml of trifluoroacetic acid (TFA) (3 times 1 ml over 6 hours) at +5° C. is added to a solution of 70 mg of the ester obtained in Stage A in 2 ml of CH2Cl2, the reaction medium is agitated for 7 hours then evaporated under reduced pressure after the addition of toluene. 0.5 ml of methanol and 1 ml of ethyl acetate are then added, and after filtration, the filtrate is poured into 10 ml of isopropyl ether to which 2 ml of pentane is added. After filtration, the solid is dried under reduced pressure and 30 mg of expected product is obtained.

Provenance & Evidence