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HRID394500

反应详情

EQUATION

反应方程式

HRID 394500 的结构方程式

REACTANTS

反应物

2
结构：NCc1ccccc1
HCID7504

Benzylamine

C7H9N

结构：CCOC(=O)C1CN(C(=O)OC(C)(C)C)CCC1=O
HCID6420876

N-Boc-3-Carboethoxy-4-piperidone

C13H21NO5

PRODUCTS

生成物

1
结构：CCOC(=O)C1=C(NCc2ccccc2)CCN(C(=O)OC(C)(C)C)C1
HCID54494199

1-(1,1-Dimethylethyl) 3-ethyl 5,6-dihydro-4-[(phenylmethyl)amino]-1,3(2H)-pyridinedicarboxylate

C20H28N2O4

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

A solution of 1-tert-butoxycarbonyl-3-ethoxycarbonylpiperidin-4-one (prepared from 3-ethoxycarbonylpiperidin-4-one and di-tert-butyl-dicarbonate in dichloromethane and triethylamine) (25 g) and benzylamine (10.85 g) in toluene was heated under reflux in a Dean and Stark apparatus for 18 hours and then evaporated to dryness to give an oil.

WORKUP

后处理

  1. temperatureunder reflux in a Dean and Stark apparatus for 18 hours
  2. customevaporated to dryness
  3. customto give an oil