1-(Benzo[d][1,3]dioxol-5-yl)-N-(6-(cyclohexylmethyl)pyridin-2-yl)cyclopropanecarboxamide → 1-(Benzo[d][1,3]dioxol-5-yl)-N-(6-isobutylpyridin-2-yl)cyclopropanecarboxamide

HRID 39458Notes

Reaction equation

HRID 39458 reaction equation
O1C2C=CC(C3(C(NC4C=CC=C(Br)N=4)=O)CC3)=CC=2OC1.[Cl-].C([Zn+])C(C)C.[O:29]1[C:33]2[CH:34]=[CH:35][C:36]([C:38]3([C:41]([NH:43][C:44]4[CH:49]=[CH:48][CH:47]=[C:46]([CH2:50][CH:51]5[CH2:56]CCC[CH2:52]5)[N:45]=4)=[O:42])[CH2:40][CH2:39]3)=[CH:37][C:32]=2[O:31][CH2:30]1>>[O:29]1[C:33]2[CH:34]=[CH:35][C:36]([C:38]3([C:41]([NH:43][C:44]4[CH:49]=[CH:48][CH:47]=[C:46]([CH2:50][CH:51]([CH3:56])[CH3:52])[N:45]=4)=[O:42])[CH2:40][CH2:39]3)=[CH:37][C:32]=2[O:31][CH2:30]1

Participants

4

Reactant 3

HCID 578951241-(Benzo[d][1,3]dioxol-5-yl)-N-(6-(cyclohexylmethyl)pyridin-2-yl)cyclopropanecarboxamideHCID 591658951-(Benzo[d][1,3]dioxol-6-yl)-N-(6-bromopyridin-2-yl)cyclopropanecarboxamideHCID 178448260HCID 178448260, compound

Product 1

HCID 578951361-(Benzo[d][1,3]dioxol-5-yl)-N-(6-isobutylpyridin-2-yl)cyclopropanecarboxamide

Procedure

1-(Benzo[d][1,3]dioxol-5-yl)-N-(6-isobutylpyridin-2-yl)cyclopropanecarboxamide was prepared from 1-(benzo[d][1,3]dioxol-5-yl)-N-(6-bromopyridin-2-yl)cyclopropanecarboxamide and isobutylzinc(II) chloride in a manner analogous to that of 1-(benzo[d][1,3]dioxol-5-yl)-N-(6-(cyclohexylmethyl)pyridin-2-yl)cyclopropanecarboxamide.

Sources & evidence

ORD record
ord-7e641642d7ed44c3b83621a8d86e4bd7
Source dataset
uspto-grants-2013_09
Patent number
US08524910B2

Reaction notes

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