HCID 10993483, compound → HCID 11145215, compound

HRID 394588Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([C:23]#[N:24])[CH:21]=3)[N:16]([C:25]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=3)[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].FC1C=CC(N2C3C(=CC([C:48]4N[N:51]=[N:50][N:49]=4)=CC=3)C(C3CCN(C(OC(C)(C)C)=O)CC3)=C2)=CC=1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([C:23]4[N:51]=[N:50][N:49]([CH3:48])[N:24]=4)[CH:21]=3)[N:16]([C:25]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=3)[CH:15]=2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 10993483HCID 10993483, compound

HCID 178451776HCID 178451776, compound

Product 1

HCID 11145215HCID 11145215, compound

Procedure

Following the procedure in Example 8, the cyanoderivative 12a was converted to the corresponding 5-[1-(4-fluorophenyl)-3-(1-t-butyloxycarbonyl-4-piperidinyl)-5-(5-tetra-zolyl)-1H-indole which was methylated according to the procedure in Example 9 to give the title compound 13a.

Sources & evidence

ORD record: ord-c187696a6c0445ae89d5bc3457d2b772
Source dataset: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06602889B1

Reaction notes

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