反应详情

The title compound is prepared as described in EXAMPLE 56, Part A using 5′-chloro-[2,2′]bithiophenyl-5-sulfonyl chloride and 2-[3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester as starting material. The crude product can be purified by column chromatography eluting with 5% MeOH/CH2Cl2to give the title compound as a white solid or used in the subsequent step after an aqueous work-up without further purification. Ion spray MS, [M+H]+=593, 595, Cl pattern.

1. customThe title compound is prepared
2. customThe crude product can be purified by column chromatography
3. washeluting with 5% MeOH/