HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,7-Dimethoxy-1-naphthaldehyde → 2-Hydroxy-7-methoxy-1-naphthaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,7-Dimethoxy-1-naphthaldehyde | HCID 293215 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Hydroxy-7-methoxy-1-naphthaldehyde | HCID 10536097 | — |
Reaction Steps
After the dimethoxylated product obtained in Step B (2 g: 9.25 mmol) has been dissolved in anhydrous dichloromethane, 97% BBr3Me2S complex (2.98 g: 9.25 mmol 1 eq.) is introduced at ambient temperature. After 35 minutes of stirring, hydrolysis is carried out with a saturated solution of sodium hydrogen carbonate (pH=8). The product is extracted with dichloromethane and then purified on a silica column AcOEt/PE (3/7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06602903B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-5a25d206ef51471592c996cba73b51c0 |
| Source note | uspto-grants-2003_08 |