HCID 18177424, compound → HCID 15391795, compound

HRID 394693Notes

Reaction equation

HRID 394693 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[O:9][CH2:8][CH:7]([C:13]#[N:14])[CH2:6]2.[H-].[Al+3].[Li+].[H-].[H-].[H-]>CCOCC>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[O:9][CH2:8][CH:7]([CH2:13][NH2:14])[CH2:6]2

Participants

4

Reactant 2

HCID 18177424HCID 18177424, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 15391795HCID 15391795, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

0.51 g (2.7 mmol) of the nitrile obtained in Step A is reduced with lithium aluminium hydride in ether to yield the title amine in the form of a yellow oil.

Sources & evidence

ORD record
ord-f5fda22431c641d6b3bb586f1cd1dd6d
Source dataset
uspto-grants-2003_08
Patent number
US06602903B2

Reaction notes

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