Acetic Anhydride → HCID 18177412, compound

HRID 394699Notes

Reaction equation

HRID 394699 reaction equation
[CH2:1]([O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[O:13][CH2:12][C:11]([CH2:17][NH2:18])=[CH:10]2)[CH2:2][CH2:3][CH2:4][CH3:5].[C:19](OC(=O)C)(=[O:21])[CH3:20]>N1C=CC=CC=1>[CH2:1]([O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[O:13][CH2:12][C:11]([CH2:17][NH:18][C:19](=[O:21])[CH3:20])=[CH:10]2)[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 18177431HCID 18177431, compound

Product 1

HCID 18177412HCID 18177412, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

0.34 g (1.38 mmol) of the amine obtained in Step F is acetylated with acetic anhydride in pyridine according to the usual procedure. The crude product of that reaction is purified on a silica column (eluant: ethyl acetate) to yield the title acetamide in the form of a white solid.

Workup

  1. customThe crude product of that reaction is purified on a silica column (eluant: ethyl acetate)

Sources & evidence

ORD record
ord-fe84e1436d0a416fb663d7c8c716ead0
Source dataset
uspto-grants-2003_08
Patent number
US06602903B2

Reaction notes

Loading…