HuagongsheHuagongshe Chemistry Print Report · For research reference only
trans-Crotonyl chloride → HCID 5328982, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | trans-Crotonyl chloride | HCID 643131 | — |
| Reactant | N4-(3-Bromophenyl)quinazoline-4,6-diamine | HCID 5328042 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 5328982 | HCID 5328982 | 52% |
Reaction Steps
To a solution of 6-amino-4-[(3-bromophenyl)amino]quinazoline (316 mg, 1.0 mmol) in THF (6 mL) stirred under N2 at 0° C. was added trans-crotonyl chloride. A yellow solid formed upon addition. The solid was collected by Buchner filtration after 2.5 hours and sonicated with EtOAc to give the title compound (216 mg, 52%), mp 279-281° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06602863B1 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-f90fa906160e4322933d49ecb7f0a8bd |
| Source note | uspto-grants-2003_08 |