反应详情

温度

25 °C

A solution of 2-chloro-3-nitrobenzamide (1.02 g, 4.9 mmol) in P2O5/(TMS)2O/1,2-dichloroethane (30 mL) was heated at 85° C. for 18 hours. After it was cooled to 25° C., the solution was filtered through a plug of silica gel (60 mL), eluting with 5% methanol/CHCl3 (400 mL). The combined washes were concentrated under reduced pressure to give 2-chloro-3-nitrobenzonitrile as an off-white solid (0.66 g, 74%).

1. filtrationthe solution was filtered through a plug of silica gel (60 mL)
2. washeluting with 5% methanol/CHCl3 (400 mL)
3. concentrationThe combined washes were concentrated under reduced pressure