Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Bromoaniline | HCID 11562 | — |
| Reactant | HCID 10801669 | HCID 10801669 | — |
| Reactant | 3-Bromoaniline--hydrogen chloride (1/1) | HCID 22736826 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 5328418 | HCID 5328418 | 67% |
Reaction Steps
A mixture of 4-chloro-6-nitrobenzothienopyrimidine (166 mg, 0.62 mmol), m-bromoaniline (0.08 mL, 0.73 mmol) and m-bromoaniline hydrochloride (144 mg, 0.69 mmol) in isopropanol (4.5 mL) was heated at 85° C. stirring under N2 for 7.5 hours. The dark brown solid was collected by Buchner filtration and washed with isopropanol and air dried to give 4-([3-bromophenyl]amino)-6-nitrobenzothieno[3,2-d]pyrimidine (145 mg, 67%), mp 247.0-248.1° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06602863B1 |
|---|
| Source dataset | uspto-grants-2003_08 |
|---|
| ORD ID | ord-1b3ccfaf5b834b76ad72b25503d22862 |
|---|
| Source note | uspto-grants-2003_08 |
|---|
