HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Carbonate → Methyl 3-(3-bromo-4-fluorophenyl)-3-oxopropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Carbonate | HCID 12021 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-(3-Bromo-4-fluorophenyl)ethan-1-one | HCID 70508 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 3-(3-bromo-4-fluorophenyl)-3-oxopropanoate | HCID 18177311 | — |
Reaction Steps
To a suspension of sodium hydride (1.1 g of 60% suspension in mineral oil, hexane-washed, 27.6 mmol) in 50 mL of tetrahydrofuran was added dimethyl carbonate (2.3 mL, 27.6 mmol) and 3′-bromo-4′-fluoroacetophenone (3.0 g, 13.8 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06602895B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-dbb88e9370cb47f2a53f1c0b85d21cb2 |
| Source note | uspto-grants-2003_08 |