HRID394821

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID299600

Methyl 2-[(2-chlorophenyl)methylidene]-3-oxobutanoate

C12H11ClO3

$结构：CCOC(=O)/C=C(\N)COCCN1C(=O)c2ccccc2C1=O$

HCID11174576

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C1=C(COCCN2C(=O)c3ccccc3C2=O)NC(C)=C(C(=O)OC)C1c1ccccc1Cl

HCID9871958

Phthalimidoamlodipine

C28H27ClN2O7

收率 70%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

2 次

PROCEDURE

实验过程

24.0 g (75.4 mmoles) of ethyl 3-amino-4-(2-(phthalimido)ethoxy)crotonate and 18.9 g (79.2 mmoles) of methyl 2-(2-chlorobenzylidene)acetoacetate in 64 ml of ethanol were heated under reflux for 20 hours. The reaction mixture was diluted with 56 ml of ethanol and was cooled to crystallise the product. 14.2 g (yield 70%) of 4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-(2-phthalimidoethoxy)methyl-1,4-dihydropyridine were obtained.

WORKUP

后处理

temperatureunder reflux for 20 hours
temperaturewas cooled
customto crystallise the product