5-[5-(4-bromophenyl)-4-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide → 5-{5-[4-(1,3-Thiazol-4-yl)-3-(trifluoromethyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide

HRID 394867Notes

Reaction equation

HRID 394867 reaction equation
BrC1C=CC(C2N([C:13]3C=C[C:16]([S:19](N)(=O)=O)=[N:17][CH:18]=3)N=C(C(F)(F)F)C=2)=CC=1C(F)(F)F.Br[C:32]1[CH:37]=[CH:36][C:35]([C:38]2[N:42]([C:43]3[CH:44]=[CH:45][C:46]([S:49]([NH2:52])(=[O:51])=[O:50])=[N:47][CH:48]=3)[N:41]=[C:40]([C:53]([F:56])([F:55])[F:54])[C:39]=2Cl)=[CH:34][CH:33]=1>>[S:19]1[CH:13]=[C:18]([C:32]2[CH:33]=[CH:34][C:35]([C:38]3[N:42]([C:43]4[CH:44]=[CH:45][C:46]([S:49]([NH2:52])(=[O:50])=[O:51])=[N:47][CH:48]=4)[N:41]=[C:40]([C:53]([F:56])([F:55])[F:54])[CH:39]=3)=[CH:36][C:37]=2[C:53]([F:56])([F:55])[F:54])[N:17]=[CH:16]1

Participants

3

Reactant 2

HCID 223138055-[5-(4-bromophenyl)-4-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamideHCID 223138135-{5-[4-bromo-3-(trifluoromethyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide

Product 1

HCID 223138495-{5-[4-(1,3-Thiazol-4-yl)-3-(trifluoromethyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide

Procedure

The title compound was prepared according to the procedure of step 3, 4 in the example 4 using 5-{5-[4-bromo-3-(trifluoromethyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide, instead of 5-[5-(4-bromophenyl)-4-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide.

Sources & evidence

ORD record
ord-b27a71c737314829a35b12fe40a24368
Source dataset
uspto-grants-2003_08
Patent number
US06603008B1

Reaction notes

Loading…