5-{4-Chloro-5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide → 5-[4-Ethyl-5-[4-(1,3-thiazol-5-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide Hydrochloride

HRID 394874Notes

Reaction equation

HRID 394874 reaction equation
[CH2:1]([C:3]1[C:4]([C:29]([F:32])([F:31])[F:30])=[N:5][N:6]([C:19]2[CH:20]=[CH:21][C:22]([S:25]([NH2:28])(=[O:27])=[O:26])=[N:23][CH:24]=2)[C:7]=1[C:8]1[CH:13]=[CH:12][C:11]([C:14]2[S:18][CH:17]=[N:16][CH:15]=2)=[CH:10][CH:9]=1)[CH3:2].[Cl:33]C1C(C(F)(F)F)=NN(C2C=CC(S(N)(=O)=O)=NC=2)C=1C1C=CC(C2N=CSC=2)=CC=1>>[ClH:33].[CH2:1]([C:3]1[C:4]([C:29]([F:32])([F:31])[F:30])=[N:5][N:6]([C:19]2[CH:20]=[CH:21][C:22]([S:25]([NH2:28])(=[O:27])=[O:26])=[N:23][CH:24]=2)[C:7]=1[C:8]1[CH:13]=[CH:12][C:11]([C:14]2[S:18][CH:17]=[N:16][CH:15]=2)=[CH:10][CH:9]=1)[CH3:2]

Participants

3

Reactant 2

HCID 120965915-{4-Chloro-5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamideHCID 178121425-[4-ethyl-5-[4-(1,3-thiazol-5-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-pyridinesulfonamide

Product 1

HCID 223138455-[4-Ethyl-5-[4-(1,3-thiazol-5-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide Hydrochloride

Procedure

The title compound was prepared according to the procedure of Example 4 step 4 using 5-[4-ethyl-5-[4-(1,3-thiazol-5-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide, instead of 5-{4-chloro-5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide.

Sources & evidence

ORD record
ord-900c76db561b491f9f1f50c6211c18a4
Source dataset
uspto-grants-2003_08
Patent number
US06603008B1

Reaction notes

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