5-[5-(4-bromophenyl)-4-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide → 5-{4-Fluoro-5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide

HRID 394877Notes

Reaction equation

HRID 394877 reaction equation
[F:1][C:2]1[C:3]([C:24]([F:27])([F:26])[F:25])=[N:4][N:5]([C:14]2[CH:15]=[CH:16][C:17]([S:20]([NH2:23])(=[O:22])=[O:21])=[N:18][CH:19]=2)[C:6]=1[C:7]1[CH:12]=[CH:11][C:10](Br)=[CH:9][CH:8]=1.BrC1C=CC(C2N([C:40]3C=C[C:43]([S:46](N)(=O)=O)=[N:44][CH:45]=3)N=C(C(F)(F)F)C=2Cl)=CC=1>>[F:1][C:2]1[C:3]([C:24]([F:27])([F:26])[F:25])=[N:4][N:5]([C:14]2[CH:15]=[CH:16][C:17]([S:20]([NH2:23])(=[O:22])=[O:21])=[N:18][CH:19]=2)[C:6]=1[C:7]1[CH:12]=[CH:11][C:10]([C:45]2[N:44]=[CH:43][S:46][CH:40]=2)=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 223138055-[5-(4-bromophenyl)-4-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamideHCID 223138165-[4-fluoro-5-(4-bromophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide

Product 1

HCID 102270275-{4-Fluoro-5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide

Procedure

The title compound was prepared according to the procedure of step 3 in the Example 4 using 5-[4-fluoro-5-(4-bromophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide, instead of 5-[5-(4-bromophenyl)-4-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide.

Sources & evidence

ORD record
ord-56b94e367c06464088c66d5ff7be08e0
Source dataset
uspto-grants-2003_08
Patent number
US06603008B1

Reaction notes

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