5-[4-ethyl-5-[4-(1,3-thiazol-5-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-pyridinesulfonamide → 5-{4-Fluoro-5-[4-(1,3-thiazol-5-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide

HRID 394879Notes

Reaction equation

HRID 394879 reaction equation
C([C:3]1[C:4]([C:29]([F:32])([F:31])[F:30])=[N:5][N:6]([C:19]2[CH:20]=[CH:21][C:22]([S:25]([NH2:28])(=[O:27])=[O:26])=[N:23][CH:24]=2)[C:7]=1[C:8]1[CH:13]=[CH:12][C:11]([C:14]2[S:18][CH:17]=[N:16][CH:15]=2)=[CH:10][CH:9]=1)C.BrC1C=CC(C2(CC)N(C3C=CC(S(N)(=O)=O)=NC=3)NC(C(F)(F)[F:56])=C2)=CC=1>>[F:56][C:3]1[C:4]([C:29]([F:31])([F:30])[F:32])=[N:5][N:6]([C:19]2[CH:20]=[CH:21][C:22]([S:25]([NH2:28])(=[O:26])=[O:27])=[N:23][CH:24]=2)[C:7]=1[C:8]1[CH:9]=[CH:10][C:11]([C:14]2[S:18][CH:17]=[N:16][CH:15]=2)=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 178121425-[4-ethyl-5-[4-(1,3-thiazol-5-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-pyridinesulfonamideHCID 223138375-[5-(4-bromophenyl)-5-ethyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide

Product 1

HCID 102988095-{4-Fluoro-5-[4-(1,3-thiazol-5-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide

Procedure

The title compound was prepared according to the procedure of step 1 in the Example 10 using 5-[4-fluoro-5-(4-bromophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide (Example 8, step 1), instead of 5-[5-(4-bromophenyl)-5-ethyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide.

Sources & evidence

ORD record
ord-88903656fb9e4d219063dcc825585740
Source dataset
uspto-grants-2003_08
Patent number
US06603008B1

Reaction notes

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